Tentative Program Schedule
Friday October 8, 2021
Subject to modification
8:00 – 8:05 am Welcome and Introduction Dr. Sergio Giralt
8:05 – 8:40 am Session I: Keynote Lecture – Relapse Post Transplant, Where are we now? Dr. Robert Soiffer
8:40 – 11:00 am Session II: Mechanisms of Relapse – Radio-Chemo Resistance and Immune Escape
11:00 - 11:15 am Break
11:15 am – 12:20 pm Session III: Measurable Residual Disease / Pre-emptive Therapy Moderators: Dr. Michael Pulsipher & Dr. Karl Peggs
12:20 – 1:00 pm Strolling Lunch - Vendor Exhibits, Abstract Posters
1:00 – 1:35 pm Session IV: Keynote Lecture – Optimal Cells for Immunotherapy Dr. Joseph Fraietta
1:35 - 2:50 pm Session V: T Cell Exhaustion and Checkpoint Blockade Moderators: Dr. Krishna Komanduri & Dr. Nirali Shah
2:50 – 3:15 pm Break
3:15 – 4:45 pm Session VI: Relapse Prevention – Drugs and Cells Moderators: Dr. Charles Craddock & Dr. John DiPersio
4:45 – 5:00 pm Break
5:00 – 6:00 pm Session VII: Best Abstracts (4 Best Abstracts 2 Basic/2 Clinical) 15 min each
6:00 – 7:30 pm Welcome Reception, Vendor Exhibits and Poster Viewing
Saturday October 9, 2021
Subject to modifications
8:00 – 8:35 am Session VIII Keynote Lecture – CAR T Cells What is next? Dr. Michel Sadelain
8:35 – 9:50 am Session IX: Mechanisms of Relapse Microbiota -T Cell Trafficking - Immune Reconstitution Moderators: Dr. Takanori Teshima &
Dr. Veronika Bachanova
9:50 – 10:00 am Break
10:00 – 11:45 am Session X: Off the Shelf Cell Therapy Products – Allo CAR T Cells and Beyond Moderators: Dr. Catherine Bollard & Dr. Melody Smith
11:45 – 12:45 pm Strolling Lunch - Vendor Exhibits, Abstract Posters
12:15 - 12:45 pm Lunch Debate: Is Haplo Transplant Associated with a Lower Relapse Rate (Defending Yes Dr. Huong / Defending No Dr. Brenda Sandmaier)
12:45 – 2:15 pm Session XI: Treatment of Relapse Moderators: Dr. David Porter & Dr. Peter Dreger
2:15 – 3:30 pm Session XII: Relapse Post Auto and CAR T Cells – It’s NOT ALL ABOUT ALLO Moderators: Dr. Sergio Giralt & Dr. Mary Horowitz
3:30 – 4:00 pm Session XIII: Summary and Future Directions Dr. Alan Wayne
4:00 pm Adjourn
Subject to modification
8:00 – 8:05 am Welcome and Introduction Dr. Sergio Giralt
8:05 – 8:40 am Session I: Keynote Lecture – Relapse Post Transplant, Where are we now? Dr. Robert Soiffer
8:40 – 11:00 am Session II: Mechanisms of Relapse – Radio-Chemo Resistance and Immune Escape
- Session IIa: Radio-Chemo Resistance Moderators: Dr. David Ritchie & Dr. Boglarka Gyurkocza
- 8:40-8:55 am Optimal Drug Dosing and New Regimens Dr. JJ Boelens
- 8:55-9:10 am Mechanisms of Radio Resistance Dr. Ralph Weichselbaum
- 9:10-9:30 am Panel Discussion and Question
- Session IIb: Immune Escape Moderators: Dr. Katherine Hsu & Dr. Luca Vago
- 9:30-9:45 am Donor Selection and Graft Source Dr. Effie Petersdorf
- 9:45-10:00 am Epigenetics of Leukemia Relapse Dr. Valentina Gambacorta
- 10:00-10:15 am Loss of NKG2D Ligands as Relapse Mechanism Dr. Anna Paczulla
- 10:15-10:30 am Myeloma Immune Escape After Auto HCT Dr. Simone Minnie
- 10:30-11:00 am Panel Discussion and Questions
11:00 - 11:15 am Break
11:15 am – 12:20 pm Session III: Measurable Residual Disease / Pre-emptive Therapy Moderators: Dr. Michael Pulsipher & Dr. Karl Peggs
- 11:15-11:30 am Lessons from MaVsRIC Dr. Christopher Hourigan
- 11:30-11:45 am MRD Lessons from the IMPACT FIGARO trial Dr. Charles Craddock
- 11:45 am-12:00 pm Monitoring with FACS and NextGen Dr. Matt Walter
- 12:00-12:20 pm Panel Discussion and Questions
12:20 – 1:00 pm Strolling Lunch - Vendor Exhibits, Abstract Posters
1:00 – 1:35 pm Session IV: Keynote Lecture – Optimal Cells for Immunotherapy Dr. Joseph Fraietta
1:35 - 2:50 pm Session V: T Cell Exhaustion and Checkpoint Blockade Moderators: Dr. Krishna Komanduri & Dr. Nirali Shah
- 1:35-1:50 pm Utilizing Checkpoint Blockade to Enhance CAR T-cell Function Dr. Crystal Mackall
- 1:50-2:05 pm Preventing Resistance to CAR T-cell Exhaustion/Exhaustion Following Relapse for Myeloid Malignancies Dr. Philip Greenberg
- 2:05-2:20 pm Immune Checkpoint Blockade in the peri-HSCT Setting (toxicity/experience/outcomes) Dr. Philippe Armand
- 2:20-2:50 pm Panel Discussion and Questions
2:50 – 3:15 pm Break
3:15 – 4:45 pm Session VI: Relapse Prevention – Drugs and Cells Moderators: Dr. Charles Craddock & Dr. John DiPersio
- 3:15-3:30 pm Challenges in Study Designs for Relapse Prevention, Defining High Risk – Power Calculations – Effect Size, Alternative Trial Designs- Dr. Brent Logan
- 3:30-3:45 pm Aza and Combinations Dr. Marcos de Lima
- 3:45-4:00 pm Targeted Therapy Dr. Mark Levis
- 4:00-4:15 pm Cellular Therapy (DLI CARS TCRS and MILS) Dr. Christoph Schmid
- 4:15-4:45 pm Panel Discussion and Questions
4:45 – 5:00 pm Break
5:00 – 6:00 pm Session VII: Best Abstracts (4 Best Abstracts 2 Basic/2 Clinical) 15 min each
6:00 – 7:30 pm Welcome Reception, Vendor Exhibits and Poster Viewing
Saturday October 9, 2021
Subject to modifications
8:00 – 8:35 am Session VIII Keynote Lecture – CAR T Cells What is next? Dr. Michel Sadelain
8:35 – 9:50 am Session IX: Mechanisms of Relapse Microbiota -T Cell Trafficking - Immune Reconstitution Moderators: Dr. Takanori Teshima &
Dr. Veronika Bachanova
- 8:35-8:50 am T Cell Trafficking and Relapse Dr. Jaebok Choi
- 8:50-9:05 am Harnessin NK Immune Reconstitution and Mechanisms of Relapse Dr. Ritzwan Romee
- 9:05-9:20 am Microbiota and Relapse Dr. Jonathan Peled
- 9:20-9:50 am Panel Discussion and Questions
9:50 – 10:00 am Break
10:00 – 11:45 am Session X: Off the Shelf Cell Therapy Products – Allo CAR T Cells and Beyond Moderators: Dr. Catherine Bollard & Dr. Melody Smith
- 10:00-10:15 am Allo VSTs for Patients Post BMT Dr. Susan Prockop
- 10:15-10:30 am Alloreactivity/GVL Effect of “Off the Shelf” VSTs Dr. Catherine Bollard
- 10:30-10:45 am Off the Shelf NK Cells and iNKT Cells as Platform for Cell Therapy Dr. Rayne Rouce
- 10:45-11:00 am Cell Engineering to Create Off the Shelf CAR T Dr. Martin Pule
- 11:00-11:15 am Practical Aspect of Allo CAR T Cell Therapy Dr. Melody Smith
- 11:15-11:45 am Panel Discussion and Questions
11:45 – 12:45 pm Strolling Lunch - Vendor Exhibits, Abstract Posters
12:15 - 12:45 pm Lunch Debate: Is Haplo Transplant Associated with a Lower Relapse Rate (Defending Yes Dr. Huong / Defending No Dr. Brenda Sandmaier)
12:45 – 2:15 pm Session XI: Treatment of Relapse Moderators: Dr. David Porter & Dr. Peter Dreger
- 12:45-1:00 pm Myeloma Dr. H. Einsele
- 1:00-1:15 pm Lymphoma Dr. Mehdi Hamadani
- 1:15-1:30 pm Myeloid Leukemia Dr. Thomas Schröder
- 1:30-1:45 pm Myelofibrosis Dr. Nicolaus Kröger
- 1:45-2:15 pm Panel Discussion and Questions
2:15 – 3:30 pm Session XII: Relapse Post Auto and CAR T Cells – It’s NOT ALL ABOUT ALLO Moderators: Dr. Sergio Giralt & Dr. Mary Horowitz
- 2:15-2:30 pm Relapse Post Auto – How bad is it? Dr. Mary Horowitz
- 2:30-2:45 pm Prevention Strategies Post Auto MM / NHL Dr. Philip McCarthy
- 2:45-3:00 pm Relapse Post CAR Dr. Michael Bishop
- 3:00-3:30 pm Panel Discussion and Questions
3:30 – 4:00 pm Session XIII: Summary and Future Directions Dr. Alan Wayne
4:00 pm Adjourn
