Tentative Program Schedule 

Friday October 8, 2021
​Subject to modification
8:00 – 8:05 am Welcome and Introduction Dr. Sergio Giralt

8:05 – 8:40 am Session I: Keynote Lecture – Relapse Post Transplant, Where are we now?  Dr. Robert Soiffer 

8:40 – 11:00 am Session II: Mechanisms of Relapse – Radio-Chemo Resistance and Immune Escape
  • Session IIa: Radio-Chemo Resistance Moderators: Dr. David Ritchie & Dr. Boglarka Gyurkocza
    • 8:40-8:55 am  Optimal Drug Dosing and New Regimens Dr. JJ Boelens
    • 8:55-9:10 am Mechanisms of Radio Resistance Dr. Ralph Weichselbaum   
    • 9:10-9:30 am  Panel Discussion and Question
  • Session IIb: Immune Escape Moderators: Dr. Katherine Hsu & Dr. Luca Vago
    • 9:30-9:45 am  Donor Selection and Graft Source Dr. Effie Petersdorf
    • 9:45-10:00 am  Epigenetics of Leukemia Relapse Dr. Valentina Gambacorta
    • 10:00-10:15 am  Loss of NKG2D Ligands as Relapse Mechanism Dr. Anna Paczulla
    • 10:15-10:30 am  Myeloma Immune Escape After Auto HCT Dr. Simone Minnie
    • 10:30-11:00 am Panel Discussion and Questions
 
11:00 - 11:15 am Break

11:15 am – 12:20 pm Session III: Measurable Residual Disease / Pre-emptive Therapy Moderators: Dr. Michael Pulsipher & Dr. Karl Peggs
  • 11:15-11:30 am Lessons from MaVsRIC Dr. Christopher Hourigan 
  • 11:30-11:45 am MRD Lessons from the IMPACT FIGARO trial Dr. Charles Craddock
  • 11:45 am-12:00 pm  Monitoring with FACS and NextGen Dr. Matt Walter
  • 12:00-12:15pm Optimizing Conditioning Regimen
  • 12:15-12:30 pm  Panel Discussion and Questions
 
12:30 – 1:30 pm Strolling Lunch - Vendor Exhibits, Abstract Posters
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1:30 – 2:05 pm Session IV: Keynote Lecture – Optimal Cells for Immunotherapy Dr. Joseph Fraietta  
 
2:05 - 3:15 pm Session V: T Cell Exhaustion and Checkpoint Blockade Moderators: Dr. Krishna Komanduri & Dr. Nirali Shah
  • 2:05-2:15 pm Utilizing Checkpoint Blockade to Enhance CAR T-cell Function Dr. Crystal Mackall
  • 2:15-2:30 pm Preventing Resistance to CAR T-cell Exhaustion/Exhaustion Following Relapse for Myeloid Malignancies Dr. Philip Greenberg
  • 2:30-2:45 pm Immune Checkpoint Blockade in the peri-HSCT Setting (toxicity/experience/outcomes) Dr. Philippe Armand
  • 2:45-3:15 pm Panel Discussion and Questions
 
3:15 - 3:30 pm Break

3:30 – 5:00 pm Session VI: Relapse Prevention – Drugs and Cells Moderators: Dr. Charles Craddock & Dr. John DiPersio
  • 3:30-3:45 pm Challenges in Study Designs for Relapse Prevention, Defining High Risk – Power Calculations – Effect Size, Alternative Trial Designs- Dr. Brent Logan 
  • 3:45-4:00 pm Aza and Combinations Dr. Marcos de Lima
  • 4:00-4:15 pm Targeted Therapy Dr. Mark Levis    
  • 4:15-4:30 pm Cellular Therapy (DLI CARS TCRS and MILS) Dr. Christoph Schmid 
  • 4:30-5:00 pm Panel Discussion and Questions
 
5:00 – 6:00 pm Session VII: Best Abstracts  (4 Best Abstracts 2 Basic/2 Clinical) 15 min each

6:00 – 7:30 pm Welcome Reception, Vendor Exhibits and Poster Viewing

​Saturday October 9, 2021   
​Subject to modifications
8:00 – 8:35 am Session VIII Keynote Lecture – CAR T Cells What is next? Dr. Michel Sadelain 

8:35 – 9:50 am Session IX: Mechanisms of Relapse Microbiota -T Cell Trafficking - Immune Reconstitution Moderators: Dr. Takanori Teshima &
Dr. Veronika Bachanova
  • 8:35-8:50 am  T Cell Trafficking and Relapse Dr. Jaebok Choi 
  • 8:50-9:05 am  Harnessing NK Immune Reconstitution and Mechanisms of Relapse Dr. Rizwan Romee
  • 9:05-9:20 am  Microbiota and Relapse Dr. Jonathan Peled 
  • 9:20-9:50 am  Panel Discussion and Questions
 
9:50 – 10:00 am Break

10:00 – 11:45 am Session X: Off the Shelf Cell Therapy Products – Allo CAR T Cells and Beyond Moderators: Dr. Catherine Bollard & Dr. Melody Smith
  • 10:00-10:15 am  Allo VSTs for Patients Post BMT Dr. Susan Prockop
  • 10:15-10:30 am  Alloreactivity/GVL Effect of “Off the Shelf” VSTs  Dr. Catherine Bollard         
  • 10:30-10:45 am  Off the Shelf NK Cells and iNKT Cells as Platform for Cell Therapy Dr. Rayne Rouce
  • 10:45-11:00 am  Cell Engineering to Create Off the Shelf CAR T Dr. Martin Pule
  • 11:00-11:15 am  Practical Aspect of Allo CAR T Cell Therapy Dr. Melody Smith
  • 11:15-11:45 am  Panel Discussion and Questions
 
11:45 – 12:45 pm Strolling Lunch - Vendor Exhibits, Abstract Posters
12:15 - 12:45 pm Lunch Debate: Is Haplo Transplant Associated with a Lower Relapse Rate (Defending Yes Dr. Huong / Defending No Dr. Brenda Sandmaier)

12:45 – 2:30 pm Session XI: Treatment of Relapse Moderators: Dr. David Porter & Dr. Peter Dreger
  • 12:45-1:00 pm Myeloma Dr. H. Einsele 
  • 1:00-1:15 pm Lymphoma Dr. Mehdi Hamadani  
  • 1:15-1:30 pm Myeloid Leukemia Dr. Thomas Schröder
  • 1:30-1:45 pm Myelofibrosis Dr. Nicolaus Kröger​
  • 1:45-2:00 pm ALL Dr. Alan S. Wayne
  • 2:00-2:30 pm Panel Discussion and Questions
 
2:30 – 3:45 pm Session XII: Relapse Post Auto and CAR T Cells – It’s NOT ALL ABOUT ALLO Moderators: Dr. Sergio Giralt & Dr. Mary Horowitz
  •  2:30-2:45 pm Relapse Post Auto – How bad is it? Dr. Mary Horowitz
  •  2:45-3:00 pm Prevention Strategies Post Auto MM / NHL Dr. Philip McCarthy
  •  3:00-3:15 pm Relapse Post CAR Dr. Michael Bishop    
  • 3:15-3:45 pm Panel Discussion and Questions
 
3:45 – 4:00 pm Session XIII: Summary and Future Directions Dr. Alan S. Wayne
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4:00 pm Adjourn
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