Tentative Program Schedule
Friday October 8, 2021
Subject to modifications
8:00 – 8:05 am Welcome and Introduction Dr. Sergio Giralt
8:05 – 8:40 am Session I: Keynote Lecture – Relapse Post Transplant, Where are we now? - Dr. Robert Soiffer
8:40 – 11:00 am Session II: Mechanisms of Relapse – Radio-Chemo Resistance and Immune Escape
11:00 - 11:15 am Break
11:15 am – 12:30 pm Session III: Measurable Residual Disease / Pre-emptive Therapy - Moderator: Dr. Michael Pulsipher
12:30 – 1:30 pm Strolling Lunch - Vendor Exhibits, Abstract Posters
1:30 – 2:05 pm Session IV: Keynote Lecture – Optimal Cells for Immunotherapy - Dr. Joseph Fraietta
2:05 - 3:15 pm Session V: T Cell Exhaustion and Checkpoint Blockade - Moderators: Dr. Krishna Komanduri & Dr. Nirali Shah
3:15 - 3:30 pm Break
3:30 – 5:00 pm Session VI: Relapse Prevention – Drugs and Cells - Moderators: Dr. Charles Craddock & Dr. John DiPersio
5:00 – 6:00 pm Session VII: Best Abstracts (4 Best Abstracts 2 Basic/2 Clinical) 15 min each
6:00 – 7:30 pm Welcome Reception, Vendor Exhibits and Poster Viewing
Saturday October 9, 2021
Subject to modifications
8:00 – 8:35 am Session VIII Keynote Lecture – CAR T Cells What is next? - Dr. Michel Sadelain
8:35 – 9:50 am Session IX: Mechanisms of Relapse Microbiota - T Cell Trafficking - Immune Reconstitution - Moderators: Dr. Takanori Teshima &
Dr. Veronika Bachanova
9:50 – 10:00 am Break
10:00 – 11:45 am Session X: Off the Shelf Cell Therapy Products – Allo CAR T Cells and Beyond - Moderators: Dr. Catherine Bollard & Dr. Melody Smith
11:45 – 12:45 pm Strolling Lunch - Vendor Exhibits, Abstract Posters
12:15 - 12:45 pm Lunch Debate: Is Haplo Transplant Associated with a Lower Relapse Rate (Defending Yes Dr. Xiao-jun Huang / Defending No Dr. Brenda Sandmaier)
12:45 – 2:30 pm Session XI: Treatment of Relapse - Moderators: Dr. David Porter & Dr. Peter Dreger
2:30 – 3:45 pm Session XII: Relapse Post Auto and CAR T Cells – It’s NOT ALL ABOUT ALLO - Moderators: Dr. Sergio Giralt & Dr. Mary Horowitz
3:45 – 4:00 pm Session XIII: Summary and Future Directions - Dr. Alan S. Wayne
4:00 pm Adjourn
Subject to modifications
8:00 – 8:05 am Welcome and Introduction Dr. Sergio Giralt
8:05 – 8:40 am Session I: Keynote Lecture – Relapse Post Transplant, Where are we now? - Dr. Robert Soiffer
8:40 – 11:00 am Session II: Mechanisms of Relapse – Radio-Chemo Resistance and Immune Escape
- Session IIa: Radio-Chemo Resistance - Moderators: Dr. David Ritchie & Dr. Boglarka Gyurkocza
- 8:40-8:55 am Optimal Drug Dosing and New Regimens - Dr. JJ Boelens
- 8:55-9:10 am Mechanisms of Radio Resistance - Dr. Ralph Weichselbaum
- 9:10-9:30 am Panel Discussion and Question
- Session IIb: Immune Escape - Moderators: Dr. Katherine Hsu & Dr. Luca Vago
- 9:30-9:45 am Donor Selection and Graft Source - Dr. Effie Petersdorf
- 9:45-10:00 am Epigenetics of Leukemia Relapse - Dr. Valentina Gambacorta
- 10:00-10:15 am Loss of NKG2D Ligands as Relapse Mechanism - Dr. Claudia Lengerke
- 10:15-10:30 am Myeloma Immune Escape After Auto HCT - Dr. Simone Minnie
- 10:30-11:00 am Panel Discussion and Questions
11:00 - 11:15 am Break
11:15 am – 12:30 pm Session III: Measurable Residual Disease / Pre-emptive Therapy - Moderator: Dr. Michael Pulsipher
- 11:15-11:30 am Lessons from MaVsRIC - Dr. Christopher Hourigan
- 11:30-11:45 am MRD Lessons from the IMPACT FIGARO Trial - Dr. Charles Craddock
- 11:45 am-12:00 pm Monitoring with FACS and NextGen - Dr. Megan Jacoby
- 12:00-12:15pm Optimizing Conditioning Regimen - Dr. Bart Scott
- 12:15-12:30 pm Panel Discussion and Questions
12:30 – 1:30 pm Strolling Lunch - Vendor Exhibits, Abstract Posters
1:30 – 2:05 pm Session IV: Keynote Lecture – Optimal Cells for Immunotherapy - Dr. Joseph Fraietta
2:05 - 3:15 pm Session V: T Cell Exhaustion and Checkpoint Blockade - Moderators: Dr. Krishna Komanduri & Dr. Nirali Shah
- 2:05-2:15 pm Utilizing Checkpoint Blockade to Enhance CAR T-cell Function - Dr. Jay Spiegel
- 2:15-2:30 pm TCR Based Strategies in Overcoming Exhaustion - Dr. Philip Greenberg
- 2:30-2:45 pm T Cell Exhaustion Regulated by Non-Coding RNA - Dr. Erietta Stelekati
- 2:45-3:15 pm Panel Discussion and Questions
3:15 - 3:30 pm Break
3:30 – 5:00 pm Session VI: Relapse Prevention – Drugs and Cells - Moderators: Dr. Charles Craddock & Dr. John DiPersio
- 3:30-3:45 pm Challenges in Study Designs for Relapse Prevention, Defining High Risk – Power Calculations – Effect Size, Alternative Trial Designs
- 3:45-4:00 pm Aza and Combinations - Dr. Marcos de Lima
- 4:00-4:15 pm Targeted Therapy - Dr. Mark Levis
- 4:15-4:30 pm Cellular Therapy (DLI CARS TCRS and MILS) - Dr. Christoph Schmid
- 4:30-5:00 pm Panel Discussion and Questions
5:00 – 6:00 pm Session VII: Best Abstracts (4 Best Abstracts 2 Basic/2 Clinical) 15 min each
6:00 – 7:30 pm Welcome Reception, Vendor Exhibits and Poster Viewing
Saturday October 9, 2021
Subject to modifications
8:00 – 8:35 am Session VIII Keynote Lecture – CAR T Cells What is next? - Dr. Michel Sadelain
8:35 – 9:50 am Session IX: Mechanisms of Relapse Microbiota - T Cell Trafficking - Immune Reconstitution - Moderators: Dr. Takanori Teshima &
Dr. Veronika Bachanova
- 8:35-8:50 am T Cell Trafficking and Relapse - Dr. Jaebok Choi
- 8:50-9:05 am Harnessing NK Immune Reconstitution and Mechanisms of Relapse - Dr. Rizwan Romee
- 9:05-9:20 am Microbiota and Relapse - Dr. Jonathan Peled
- 9:20-9:50 am Panel Discussion and Questions
9:50 – 10:00 am Break
10:00 – 11:45 am Session X: Off the Shelf Cell Therapy Products – Allo CAR T Cells and Beyond - Moderators: Dr. Catherine Bollard & Dr. Melody Smith
- 10:00-10:15 am Allo VSTs for Patients Post BMT - Dr. Susan Prockop
- 10:15-10:30 am Alloreactivity/GVL Effect of “Off the Shelf” VSTs - Dr. Catherine Bollard
- 10:30-10:45 am Off the Shelf NK Cells and iNKT Cells as Platform for Cell Therapy - Dr. Rayne Rouce
- 10:45-11:00 am Cell Engineering to Create Off the Shelf CAR T - Dr. Martin Pule
- 11:00-11:15 am Practical Aspect of Allo CAR T Cell Therapy - Dr. Melody Smith
- 11:15-11:45 am Panel Discussion and Questions
11:45 – 12:45 pm Strolling Lunch - Vendor Exhibits, Abstract Posters
12:15 - 12:45 pm Lunch Debate: Is Haplo Transplant Associated with a Lower Relapse Rate (Defending Yes Dr. Xiao-jun Huang / Defending No Dr. Brenda Sandmaier)
12:45 – 2:30 pm Session XI: Treatment of Relapse - Moderators: Dr. David Porter & Dr. Peter Dreger
- 12:45-1:00 pm Myeloma - Dr. Hermann Einsele
- 1:00-1:15 pm Lymphoma - Dr. Mehdi Hamadani
- 1:15-1:30 pm Myeloid Leukemia - Dr. Thomas Schröder
- 1:30-1:45 pm Myelofibrosis - Dr. Nicolaus Kröger
- 1:45-2:00 pm ALL - Dr. Alan S. Wayne
- 2:00-2:30 pm Panel Discussion and Questions
2:30 – 3:45 pm Session XII: Relapse Post Auto and CAR T Cells – It’s NOT ALL ABOUT ALLO - Moderators: Dr. Sergio Giralt & Dr. Mary Horowitz
- 2:30-2:45 pm Relapse Post Auto – How bad is it? - Dr. Mary Horowitz
- 2:45-3:00 pm Prevention Strategies Post Auto MM / NHL - Dr. Philip McCarthy
- 3:00-3:15 pm Relapse Post CAR - Dr. Michael Bishop
- 3:15-3:45 pm Panel Discussion and Questions
3:45 – 4:00 pm Session XIII: Summary and Future Directions - Dr. Alan S. Wayne
4:00 pm Adjourn
